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COVID-19 is an evolving pandemic and has spread to over 200 countries claiming approximately 3730000 deaths. While scientists work at the forefront of developing strategies to counter this deadly virus, many have identified the significance of bacille Calmette-Guerin (BCG) vaccine against conferring immune-protection against COVID-19. This observation comes amidst a significantly lower mortality rate in countries where the BCG vaccine remains an integral part of the neonatal vaccination regimen. Even though the purpose of the vaccine in these countries is to protect against tuberculosis infection; the BCG vaccine has shown protective effects against non-mycobacterial infections and certain cancers. In this review, we highlight these observations and discuss the various vaccine-host immune interactions, particularly the role of cytokines that may have a role in conferring immuno-protection against COVID-19 in BCG vaccinated individuals.